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OPG antibody [bony-1]

Anti-OPG antibody [bony-1] used in Flow cytometry (FACS). GTX18051

Cat. No. GTX18051

Host

 Rat

Clonality

 Monoclonal

Clone Name

 bony-1

Isotype

 IgG2a

Application

 FACS, IP

Reactivity

 Human
Package
50 μg ($399)
See all OPG products

APPLICATION

Application Note

FACS: 1/1000. IP: 1/200. Optimal dilutions/concentrations should be determined by the end user.

Product Note

Recognizes human OPG

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment, corresponding to amino acids 22-202 of Human Osteoprotegerin.

Purification

>95% by SDS-PAGE

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TNF receptor superfamily member11b , OCIF , OPG , PDB5 , TNFRSF11B , TR1 , Osteoprotegerin , osteoclastogenesis inhibitory factor

Cellular Localization

Secreted

Background

Osteoprotegerin (OPG) is a member of the TNF receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of the gene have been reported, but their full length nature has not been determined.

Research Area

DATA IMAGES

Anti-OPG antibody [bony-1] used in Flow cytometry (FACS). GTX18051

GTX18051 FACS Image

FACS analysis of cells with MAb to OPG (human) (GTX18051). HEK 293T cells (5x105) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of the TNFR homology domain of human OPG (thick line). Cells were incubated on ice for 30 min. in 50μl FACS buffer (PBS, 5% fetal calf serum, 0.02% azide) containing 1μg/ml of MAb to OPG (human) (Bony-1) (GTX18051). After washing in FACS buffer, RPE-conjugated antibody to rat IgG was added. Cells were incubated on ice for 30 min, washed and then analyzed by flow cytometry.

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399